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Tetsuya Kamataki Selected Research

Methoxsalen (Oxsoralen)

7/20098-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
3/2006Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.
12/2005Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
11/2005Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
11/2003Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.

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Tetsuya Kamataki Research Topics

Disease

8Neoplasms (Cancer)
01/2012 - 06/2002
7Adenoma (Adenomas)
01/2012 - 11/2003
5Lung Neoplasms (Lung Cancer)
01/2012 - 08/2002
4Carcinogenesis
01/2012 - 08/2002
4Body Weight (Weight, Body)
07/2009 - 11/2003
4Adenocarcinoma
07/2009 - 12/2004
4Trimethylaminuria
01/2007 - 01/2002
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
07/2007 - 09/2002
3Atherosclerosis
02/2006 - 09/2005
2Adenocarcinoma of Lung
01/2012 - 07/2009
2Small Cell Carcinoma
12/2004 - 09/2002
1Hyperplasia
07/2009
1Carcinoma (Carcinomatosis)
10/2007
1Colorectal Neoplasms (Colorectal Cancer)
10/2007
1Drug-Related Side Effects and Adverse Reactions
12/2006
1Disorders of Excessive Somnolence (Hypersomnia)
12/2006
1Hepatocellular Carcinoma (Hepatoma)
02/2004
1Wasting Syndrome (Wasting Disease)
01/2004
1Gynecomastia
05/2003
1Hepatoblastoma
09/2002
1Renal Cell Carcinoma (Grawitz Tumor)
09/2002
1Stomach Neoplasms (Stomach Cancer)
06/2002
1Iron Overload
04/2002

Drug/Important Bio-Agent (IBA)

6Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
01/2012 - 12/2004
54- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA
01/2012 - 11/2003
5Methoxsalen (Oxsoralen)FDA Link
07/2009 - 11/2003
4Messenger RNA (mRNA)IBA
10/2007 - 09/2002
4NitrosaminesIBA
10/2007 - 08/2002
4SmokeIBA
10/2007 - 08/2002
4EnzymesIBA
07/2007 - 08/2002
3dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA
01/2007 - 01/2002
3Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA
02/2006 - 09/2005
2TegafurIBA
05/2008 - 06/2002
2Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
11/2005 - 09/2005
2LuciferasesIBA
02/2004 - 09/2002
2Cytochrome P-450 CYP3AIBA
02/2004 - 05/2003
1CotinineIBA
01/2012
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2012
1NicotineFDA Link
01/2012
1CaspasesIBA
01/2012
1Fluorouracil (Carac)FDA LinkGeneric
05/2008
1Proteins (Proteins, Gene)FDA Link
10/2007
1N 30IBA
10/2007
1Codon (Codons)IBA
01/2007
1DNA (Deoxyribonucleic Acid)IBA
01/2007
1CarcinogensIBA
12/2006
1Cytochrome P-450 CYP2D6 (CYP2D6)IBA
12/2006
1nitrosamine 4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA
12/2006
1Corn Oil (Oil, Corn)IBA
03/2006
1Liver X ReceptorsIBA
11/2005
1Cytochrome P-450 CYP1A1 (CYP1A1)IBA
11/2005
1steroid hormone 7-alpha-hydroxylaseIBA
11/2005
1Protein SIBA
11/2005
1LigandsIBA
09/2005
1ORALIT (ORS)IBA
12/2004
1Charcoal (Charbon)IBA
04/2004
1chlorophyllin (copper chlorophyll)IBA
04/2004
1trimethylamineIBA
04/2004
1trimethyloxamine (trimethylamine N-oxide)IBA
04/2004
1Aromatic HydrocarbonsIBA
01/2004
13 (or 17)-beta-hydroxysteroid dehydrogenaseIBA
05/2003
1Estradiol (Delestrogen)FDA LinkGeneric
05/2003
1Spironolactone (Aldactone)FDA LinkGeneric
05/2003
1trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (dihydrodiol dehydrogenase)IBA
09/2002
1NucleotidesIBA
09/2002
1Hepatocyte Nuclear FactorsIBA
09/2002
1titanium silicide (TS-1)IBA
06/2002
1gimeracilIBA
06/2002
1Pharmaceutical PreparationsIBA
06/2002
1Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
06/2002
1Capsules (Microcapsules)IBA
06/2002
1coumarinIBA
04/2002
1Ferritins (Ferritin)IBA
04/2002